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Tuesday, August 4, 2020 | History

2 edition of Partial hepatectomy in experimental carbon tetrachloride-induced liver fibroris. found in the catalog.

Partial hepatectomy in experimental carbon tetrachloride-induced liver fibroris.

Rolf Olsson

Partial hepatectomy in experimental carbon tetrachloride-induced liver fibroris.

A histological and biochemical study in rats.

by Rolf Olsson

  • 202 Want to read
  • 14 Currently reading

Published by Norstedt in Stockholm .
Written in English

    Subjects:
  • Liver -- Cirrhosis.,
  • Carbon tetrachloride -- Toxicology.

  • Edition Notes

    SeriesActa chirurgica Scandinavica. Supplementum,, 366
    Classifications
    LC ClassificationsRC848.C5 O4
    The Physical Object
    Pagination84, (1) p.
    Number of Pages84
    ID Numbers
    Open LibraryOL5379688M
    LC Control Number72386926

    Partial hepatectomy in experimental carbon tetrachloride-induced liver fibrosis. A histological and biochemical study in rats. Olsson R. Acta Chir Scand Suppl, , 01 Jan Cited by 1 . In separate experiments, the hepatic regenerative capacity and functional recovery of omega‐3 FA‐treated, saline‐treated or non‐steatotic (control) rats were investigated 1, 2, 3 and 5 days after partial (70 per cent) liver resection by measurement of liver weight change and .

    LIVER REGENERATION AFTER PARTIAL HEPATECTOMY IN CARBON TETRACHLORIDE-INDUCED CIRRHOSIS IN THE RAT N. RABINOVICI, M.D., AND E. WIENER, M.D. Surgical Department B, Hadassah University Hospital and the Surgical Research Laboratory of the Hebrew University-Hadassah Medical School, Jerusalem, Israel The normal liver has a remarkable ca­. Flavonoids are reported to exhibit a wide variety of biological effects, including antioxidant and free radical-scavenging activities. Evidence of oxidative reactions is often associated with various chronic disease processes characterized by accumulation of connective tissue. This study was aimed to investigate the protective effects of chronic administration of the flavonoid quercetin (

    Mouse model of carbon tetrachloride induced liver fibrosis: Histopathological changes and expression of CD and epidermal growth factor (). DePinho RA: Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery. Science Influence of epidermal growth factor on liver regeneration after partial hepatectomy in mice. Hepatic fibrosis underlies most types of chronic liver diseases and is characterized by excessive deposition of extracellular matrix (ECM), altered liver architecture, and impaired hepatocyte proliferation; however, the fibrotic liver can still regenerate after partial hepatectomy (PH).


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Partial hepatectomy in experimental carbon tetrachloride-induced liver fibroris by Rolf Olsson Download PDF EPUB FB2

Acta Chir Scand Suppl. ; Partial hepatectomy in experimental carbon tetrachloride-induced liver fibrosis. A histological and biochemical study in by: 3. Carbon tetrachloride (CCl 4) intoxification in rodents is a commonly used model of both acute and chronic liver ly, we showed that mice in which FGFR4 was ablated from the germline exhibited elevated cholesterol metabolism and bile acid synthesis coincident with unrepressed levels of cytochrome P 7A (CYP7A), the rate-limiting enzyme in cholesterol by:   Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and is the third leading cause of cancer mortality [].Eighty percent of HCCs develop in the context of chronic liver diseases, as chronic liver injury generally induces liver fibrosis, followed by cirrhosis [].In an attempt to model this process, carbon tetrachloride (CCl 4) has been widely used to experimentally induce Cited by: Introduction.

Liver fibrosis is a common consequence of various chronic liver diseases and the underlying pathology represents the common response of the liver to toxicity, infection or metabolism (1–3).Hepatic fibrosis, characterized by excess deposition of extracellular matrix proteins, is traditionally viewed as an irreversible pathological process involving multiple signaling pathways (4,5).Cited by: 9.

Increased procollagen mRNA levels in carbon tetrachloride-induced liver fibrosis in rats. Pierce RA, Glaug MR, Greco RS, Mackenzie JW, Boyd CD, Deak SB. J Biol Chem, (4), 01 Feb Cited by 70 articles | PMID: Cited by: 3.

Swertiamarin (STM) is an iridoid compound that is present in the Gentianaceae swertia genus. Here we investigated antiapoptotic effects of STM on carbon tetrachloride (CCl 4)-induced liver injury and its possible male Sprague Dawley rats were randomly divided into a control group, an STM mg/kg group, a CCl 4 group, a CCl 4 +STM mg/kg group, and a CCl 4 +STM.

Methods. Seven groups of adult male Wistar rats (n = 10) were used. A carbon tetrachloride (CCl 4) solution was injected intraperitoneally twice weekly for 6 the 7th week, rats developed liver fibrosis were treated either by ketanserin (1 mg/kg/day, ip) or SB (2 mg/kg/day, ip) for 14 al rates, and serum alanine aminotransferase (ALT) and aspartate.

Bengmark S, Olsson R () Biochemical studies on carbon tetrachloride- induced liver fibrosis after partial hepatectomy. Acta Chir Scand [Suppl] 44–69 Google Scholar 2. 1. Introduction. Liver, as a key organ of metabolism and excretion, is constantly endowed with the task of detoxification.

In spite of major progress in the knowledge and management of liver diseases in recent years, millioins of people still surffer from liver problems (Li et al., a, Li et al., b).Hepatic fibrosis is a common pathological process resulted from a fibrogenic response. Abstract: The effect of serotonin receptor 2 blockade (5‐HT 2) on liver regeneration after 30–34% and 60–70% partial hepatectomy in the rat liver was investigated.

Materials and methods: Male Wistar rats were subjected to 60–70% (group I) and 30–34% (group II) partial hepatectomy. Serotonin receptor 2 blockade was exerted by intraperitoneal administration of ketanserin at different. In the present study we assessed whether liver fibrosis and cirrhosis can be reversed by treatment with MSCs or fibroblasts concomitant to partial hepatectomy (pHx)‐induced liver regeneration.

After carbon tetrachloride‐induced fibrosis and cirrhosis, mice underwent a pHx and received either systemically or locally MSCs in one of the two. Unfortunately, tests that accurately predict regenerative activity in the postoperative period have yet to be described.

This study was designed to determine whether the extent of hepatic fibrosis correlates with liver regeneration activity after partial hepatectomy in rats with carbon tetrachloride–induced liver. Partial hepatectomy in experimental carbon tetrachloride-induced liver fibrosis: a histological and biochemical study in rats By Rolf Olsson Topics: Cystic fibrosis, Hepatectomy.

CCl 4 can induce serious liver injury through its metabolic bio-activation into trichloromethyl free radicals, and chronic CCl 4 administration was generally used to induce experimental liver fibrosis (Weiler-Normann et al.,Marques et al., ). For instance, by using a combination of cell lineage tracing studies and liver injury, it was shown that Sox9-expressing progenitor cells residing in the canals of Hering are the predominant source of new hepatocytes in mouse liver homeostasis, two-thirds partial hepatectomy (2/3 PH), and carbon tetrachloride intoxication or bile duct ligation.

Nouf M. Al-Rasheed, Hala A. Attia, Raeesa A. Mohamad, Nawal M. Al-Rasheed, Musaed Al Fayez, Maha A. Al-Amin, Date fruits inhibit hepatocyte apoptosis and modulate the expression of hepatocyte growth factor, cytochrome P 2E1 and heme oxygenase-1 in carbon tetrachloride-induced liver fibrosis, Archives of Physiology and Biochemistry, Carbon tetrachloride (CCL 4) is often employed in the production of chlorofluorocarbons, petroleum refining, oil and rubber processing, and laboratorysubcutaneous, and inhalation exposure to CCL 4 in animal studies have been shown to be capable of leading to various types of cancer (benign and malignant, liver, breast, and adrenal gland tumors).

Hepatic collagen synthesis and degradation during liver regeneration after partial hepatectomy. Hepatology[ Links ] Vinicius I, Baptista AP, Barbosa Jr AA, Andrade ZA. Morphological signs of cirrhosis regression. (Experimental observations on carbon-tetrachloride-induced liver cirrhosis in rats).

CX3CL1‐CX3CR1 interaction prevents carbon tetrachloride‐induced liver inflammation and fibrosis in mice † Tomonori Aoyama Division of Gastroenterology, Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA. Lianyan Jing, Shuai Zong, Jinglei Li, Ming Ye, Maheen Surahio, Liu Yang, Potential mechanism of protection effect of exopolysaccharide from Lachnum YM and its derivatives on carbon tetrachloride-induced acute liver injury in mice, Journal of Functional Foods, /, 36, (), ().

The role of the anti‐inflammatory cytokine interleukin‐10 (IL‐10) was investigated in the mouse model of liver injury induced by carbon tetrachloride (CCl 4).To address the role of endogenous IL‐10 production, acute hepatitis was induced by CCl 4 in C57Bl/6 IL‐10 gene knock out (KO) and wild‐type (WT) mice.

After CCl 4 challenge, serum and liver levels of tumor necrosis factor.Click on the article title to read more.Increased Carbon Tetrachloride-Induced Liver Injury and Fibrosis in FGFR4-Deficient Mice Article in American Journal Of Pathology (6) January with 67 Reads How we measure 'reads'.